Disease Fidelity

This page presents the currently released disease-fidelity evidence records for public review; no formal model-level conclusion is currently released.

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Current public records

Results

Formal Disease Fidelity Results: 0No model-level conclusion is currently released.

2 records

Disease	Model	Model stimulus / contrast	Reference	Reference contrast	Reference type
psoriasis	HaCaT GSE20297	TNF-alpha + IFN-gamma stimulated vs unstimulated	GSE274560	psoriasis vs healthy	keratinocyte-enriched epidermal cells
psoriasis	HaCaT GSE20297	TNF-alpha + IFN-gamma stimulated vs unstimulated	GSE173706	PP lesional vs NS healthy	scRNA-derived keratinocyte donor-level pseudobulk

Reference Design

Parallel primary model-reference comparisons

GSE274560Psoriasis reference

GSE20297Stimulated HaCaT model

GSE173706Psoriasis keratinocyte reference

Primary comparison A

Primary comparison B

Secondary reference-discrepancy diagnostic

The same HaCaT inflammatory response is assessed independently against two patient-derived references. The reference-to-reference connection is a secondary discrepancy diagnostic, not a third Disease Fidelity comparison.

Scope control

Methods

This page documents an existing technical pilot and adds no new differential expression, enrichment, pseudobulk, sample selection, or statistical analysis. Detailed public fields remain available through Downloads.

Technical status details

reference-dependentpilot_unreviewedTYPE B

The downloadable data keep significant-overlap, all-common-gene and reference-informative directional concordance as distinct fields.