CellModelDB

PUBLIC_RC1 · frozen evidence layer

Physiological Relevance

Physiological Relevance (PR) evaluates baseline similarity between a cell model and its intended normal human target-cell reference.

Browse PR assessments

Showing 15 of 15 models

15 models13 legacy PR · 2 V4 assessments

Legacy versions: V1 5 · V2 6 · V3 2

Legacy PR rows are read at build time from release_package/database/cellmodeldb.sqlite; the website does not recalculate scores.

Colon/Intestine 1

Caco-2

Entity_ID: CI-ENT-039

V2
Target reference
enterocytes · GENERAL_EPITHELIAL_CONTEXT
Spearman rho
0.707474
Rank / percentile
23/154 / 85.621%
Delta rho
-0.0680778268
NES
NOT_DEFINED
Gene-set size
921
Caveat
Tumour-control role retained; PR does not change database role.
Status
FORMAL

Kidney 2

RPTEC/TERT1

Entity_ID: KIDNEY-ENT-002

V1
Target reference
proximal tubule cells · proximal tubular epithelial
Spearman rho
0.558464
Rank / percentile
136/154 / 11.765%
Delta rho
-0.2102363253
NES
NOT_DEFINED
Gene-set size
919
Status
FORMAL

HK-2

Entity_ID: KIDNEY-ENT-001

V3
Target reference
proximal tubule cells · proximal tubular epithelial
Spearman rho
0.513163
Rank / percentile
144/154 / 6.536%
Delta rho
NOT_DEFINED
NES
NOT_DEFINED_BY_V3_NULL_SIGN
Gene-set size
919
Status
FORMAL

Liver 1

LX-2

Entity_ID: LIV-ENT-A03-009

V2
Target reference
hepatic stellate cells · HEPATIC_STELLATE
Spearman rho
0.495528
Rank / percentile
77/154 / 50.327%
Delta rho
-0.1194289265
NES
NOT_DEFINED
Gene-set size
365
Status
FORMAL

Lung 5

HBEC3-KT

Entity_ID: LUNG-ENT-012

V1
Target reference
respiratory basal cells · PROPAGATED_MODEL
Spearman rho
0.734071
Rank / percentile
16/154 / 90.196%
Delta rho
-0.0648966577
NES
NOT_DEFINED
Gene-set size
147
Status
FORMAL

A549

Entity_ID: LUNG-ENT-002

V2
Target reference
alveolar cells type 2 · TUMOUR_DERIVED_LINE
Spearman rho
0.728273
Rank / percentile
11/154 / 93.464%
Delta rho
-0.0331284011
NES
NOT_DEFINED
Gene-set size
295
Caveat
Tumour-control role retained; PR does not change database role.
Status
FORMAL

BEAS-2B

Entity_ID: LUNG-ENT-003

V2
Target reference
respiratory basal cells · PROPAGATED_MODEL
Spearman rho
0.575980
Rank / percentile
47/154 / 69.935%
Delta rho
-0.0783202076
NES
NOT_DEFINED
Gene-set size
NOT_DEFINED
Status
FORMAL

MRC-5

Entity_ID: LUNG-ENT-029

V4
Target reference
fibroblasts / PRTGT-005; accepted proxy with limitation
Assessment
V4 Formal Assessment
Replicate evidence
3 replicate results
Caveat
Replicate-level assessment; no single model-level score is aggregated.
Details
Open assessment and evidence

WI-38

Entity_ID: LUNG-ENT-039

V4
Target reference
fibroblasts / PRTGT-005; accepted proxy with limitation
Assessment
V4 Formal Assessment
Replicate evidence
3 replicate results
Caveat
Replicate-level assessment; no single model-level score is aggregated.
Details
Open assessment and evidence

Ovary 1

COV434

Entity_ID: OVARY-ENT-025

V3
Target reference
granulosa cells · Granulosa cell
Spearman rho
0.659390
Rank / percentile
30/154 / 81.046%
Delta rho
NOT_DEFINED
NES
1.095648
Gene-set size
218
Caveat
Granulosa proxy caveat retained from the frozen V3 target mapping.
Status
FORMAL

Skeletal Muscle 1

LHCN-M2

Entity_ID: SM-ENT-001

V1
Target reference
myosatellite cells · Human myoblast-derived differentiated myotube system
Spearman rho
0.691259
Rank / percentile
40/154 / 74.510%
Delta rho
-0.0538316890
NES
NOT_DEFINED
Gene-set size
241
Status
FORMAL

Skin 1

HaCaT

Entity_ID: SKIN-ENT-001

V1
Target reference
basal keratinocytes · skin/epidermis keratinocyte
Spearman rho
0.766670
Rank / percentile
3/154 / 98.693%
Delta rho
-0.0342592142
NES
NOT_DEFINED
Gene-set size
289
Status
FORMAL

Vascular 3

TIME

Entity_ID: vasc-ent-001

V1
Target reference
vascular endothelial cells · TIME
Spearman rho
0.738020
Rank / percentile
1/154 / 100.000%
Delta rho
0.0000000000
NES
NOT_DEFINED
Gene-set size
454
Status
FORMAL

HMEC-1

Entity_ID: vasc-ent-003

V2
Target reference
vascular endothelial cells · HMEC-1
Spearman rho
0.750336
Rank / percentile
7/154 / 95.556%
Delta rho
-0.0141165373
NES
NOT_DEFINED
Gene-set size
454
Status
FORMAL

hCMEC/D3

Entity_ID: vasc-ent-004

V2
Target reference
vascular endothelial cells · hCMEC/D3
Spearman rho
0.720691
Rank / percentile
17/154 / 89.542%
Delta rho
-0.0246914376
NES
NOT_DEFINED
Gene-set size
NOT_DEFINED
Status
FORMAL

PR definition

PR compares a model's baseline expression state with a prespecified normal human target-cell reference. It is an evidence layer, not a universal model ranking or a measure of overall model quality.

PR ≠ overall model quality · PR ≠ universal ranking · PR ≠ Disease Fidelity · PR and DF are independent.

PR status semantics

FORMAL
Frozen reportable PR result in the approved public release.
HOLD
Retained governance status; not zero, failed, or low PR.
EXPLORATORY
Contextual or pilot evidence, not included in the formal count.
NOT_ASSESSED
No formal PR assessment is available in PUBLIC_RC1; this is not a low-relevance conclusion.

Disease Fidelity addresses stimulus-response similarity to patient disease. The current HaCaT psoriasis pilot is not a validated Disease Fidelity result.

Release boundary
Legacy formal PR accounting remains 13 (V1=5, V2=6, V3=2), separate from 2 V4 assessments. This page does not generate a combined count, composite score, recommendation, or new scientific result.